In determining a treatment strategy for a patient with CAD, there are a variety of considerations that need to be made when selecting the appropriate treatment: Clinical outcomes differ significantly according to the treatment choice, as has been demonstrated by currently available data from the COURAGE, FREEDOM and SYNTAX trials, and emphasize that CABG is superior in the long-term treatment of revascularization in some patients with two-vessel …
The FAME 1&2 Trials
In 1995 Topol[1] first described what vascular surgeons have known for many years: The pressure drop in a fluid flowing through a long cylindrical pipe such as a stenotic artery becomes functionally significant when the obstruction exceeds 70%, first described in the Poiseuille law in 1846[2]. As was stated in Topol’s paper: “Accordingly, before the residual stenosis in an infarct …
Chronic anticoagulation in atrial fibrillation
A few days ago I published an article called fatalities involving the new drug Dabigatran. This has resulted almost immediately in a letter from the Media Group Director of the PR company that handles advertising for the pharmaceutical firm involved. I am glad to post it here: Comment: “Just wanted to contact you with regard to your “Fatalities with Dabigatran and Warfarin …
Fatalities with Dabigatran and Warfarin Caused by Bleeding
A FDA report presented at the 2013 American College of Cardiology (ACC) 2013 Scientific Sessions has suggested a much higher case fatality rate than that reported in other major clinical trials of the drug. For the study, reports of bleeding with dabigatran or warfarin submitted to the FDA between January 1, 2010, and June 30, 2012 were examined: Adverse drug reactions …
The Mediterranean Diet Is Heart Healthy: The PREDIMED Trial
The PREDIMED Trial Comments Eligible participants were mostly older Caucasian women with no evidence of cardiovascular disease at enrollment, with either type II diabetes mellitus or at least three of the following major risk factors: smoking, hypertension, elevated LDL levels, low HDL levels, overweight or obesity, or a family history of premature coronary heart disease: Baseline Characteristics Female gender 60% Mean …
Five Things Physicians and Patients Should Question
Five Things Physicians and Patients Should Question: Don’t perform stress cardiac imaging or advanced non-invasive imaging in the initial evaluation of patients without cardiac symptoms unless high-risk markers are present. Asymptomatic, low-risk patients account for up to 45 percent of unnecessary “screening.” Testing should be performed only when the following findings are present: diabetes in patients older than 40-years-old; peripheral …
Improper Cardiac Stent Implantations
Senate Finance Committee Chairman Max Baucus (D-Mont.) and Ranking Member Chuck Grassley (R-Iowa) today released a Finance Committee report detailing the case of a doctor who reportedly implanted nearly 600 potentially medically unnecessary stents from 2007 through mid-2009 at St. Joseph Medical Center in Towson, Maryland, and his relationship with the manufacturer of the stents, Abbott Labs. The Senators’ report …
Cost-Effectiveness of PCI with Drug Eluting Stents versus CABG
Cost-Effectiveness of PCI with Drug Eluting Stents versus Bypass Surgery for Patients with Diabetes and Multi-vessel Coronary Artery Disease: Results from the FREEDOM Trial. Not only did patients with diabetes and multi-vessel CAD experience significantly better clinical outcomes after revascularization with CABG than PCI with a drug-eluting stent, according to results of the FREEDOM trial, based on lifetime projections, CABG was found to be more …
SYNTAX Trial after Five Years: Final Results
In the SYNTAX trial 1800 patients with previously untreated left-main or three-vessel disease were randomized to CABG or PCI. As expected, differences in long-term outcomes of Coronary Artery Bypass Grafting vs. PCI, already present after year one, have continued to become more obvious during the next four years: SYNTAX five-year results for patients with three-vessel disease: SYNTAX five-year results for …
Stents and Stroke
LONDON – Stroke patients over 70 who get stents to keep their arteries open may be doubling their risk of having another stroke or dying compared to patients who get surgery instead, a new study says. European researchers examined past studies from more than 3,400 stroke patients, including 1,725 who got stents and 1,708 who had surgery, and found that …